Imipenem Cilastatin Injection

Product Description

Product Name: CILAST
Composition:
Each vial contains:

• Imipenem USP 500 mg

• Cilastatin USP 500 mg
  Dosage Form: Sterile powder for injection (to be reconstituted)

Description:

CILAST is a broad-spectrum -lactam antibiotic injection containing Imipenem, a potent carbapenem antibiotic, and Cilastatin, a renal dehydropeptidase inhibitor. Cilastatin prevents the renal metabolism of Imipenem, ensuring effective therapeutic levels and enhancing its antibacterial activity.

Indications:

CILAST is indicated for the treatment of a wide variety of serious bacterial infections, including:

• Lower respiratory tract infections

• Intra-abdominal infections

• Urinary tract infections

• Gynecological infections

• Skin and soft tissue infections

• Bone and joint infections

• Septicemia

• Endocarditis (caused by susceptible organisms)

Mechanism of Action:

• Imipenem acts by inhibiting bacterial cell wall synthesis through binding to penicillin-binding proteins (PBPs), leading to cell death.

• Cilastatin inhibits the renal enzyme dehydropeptidase-I, preventing Imipenem degradation in the kidneys and extending its antibacterial activity.

Key Features:

• Ultra-broad spectrum active against Gram-positive, Gram-negative, and anaerobic bacteria

• Enhanced efficacy with Cilastatin co-administration

• Used in hospital-acquired and drug-resistant infections

• Well tolerated with a proven safety profile in severe infections

Dosage & Administration:

• Adults: 250 mg to 1 g every 6 to 8 hours IV, depending on the severity of infection

• Maximum dose: Not to exceed 4 g/day of Imipenem

• Route: Intravenous infusion over 3060 minutes

• Reconstitution and dilution instructions should be followed as per the prescribing information.

Always use under the supervision of a registered medical practitioner.

Packaging:

• Vial with dry powder

• Supplied with sterile water or as per standard hospital dilution protocols

Storage:

• Store below 25C. Protect from light and moisture.

• After reconstitution, use the solution immediately or within the specified time (usually 4 hours at room temperature or 24 hours if refrigerated).