Imipenem Cilastatin Injection

Product Description

Product Name: CILAST
Composition:
Each vial contains:

• Imipenem USP 500 mg

• Cilastatin USP 500 mg
  Dosage Form: Sterile powder for injection (to be reconstituted)

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Description:

CILAST is a broad-spectrum -lactam antibiotic injection containing Imipenem, a potent carbapenem antibiotic, and Cilastatin, a renal dehydropeptidase inhibitor. Cilastatin prevents the renal metabolism of Imipenem, ensuring effective therapeutic levels and enhancing its antibacterial activity.

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Indications:

CILAST is indicated for the treatment of a wide variety of serious bacterial infections, including:

• Lower respiratory tract infections

• Intra-abdominal infections

• Urinary tract infections

• Gynecological infections

• Skin and soft tissue infections

• Bone and joint infections

• Septicemia

• Endocarditis (caused by susceptible organisms)

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Mechanism of Action:

• Imipenem acts by inhibiting bacterial cell wall synthesis through binding to penicillin-binding proteins (PBPs), leading to cell death.

• Cilastatin inhibits the renal enzyme dehydropeptidase-I, preventing Imipenem degradation in the kidneys and extending its antibacterial activity.

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Key Features:

• Ultra-broad spectrum active against Gram-positive, Gram-negative, and anaerobic bacteria

• Enhanced efficacy with Cilastatin co-administration

• Used in hospital-acquired and drug-resistant infections

• Well tolerated with a proven safety profile in severe infections

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Dosage & Administration:

• Adults: 250 mg to 1 g every 6 to 8 hours IV, depending on the severity of infection

• Maximum dose: Not to exceed 4 g/day of Imipenem

• Route: Intravenous infusion over 3060 minutes

• Reconstitution and dilution instructions should be followed as per the prescribing information.

Always use under the supervision of a registered medical practitioner.

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Packaging:

• Vial with dry powder

• Supplied with sterile water or as per standard hospital dilution protocols

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Storage:

• Store below 25C. Protect from light and moisture.

• After reconstitution, use the solution immediately or within the specified time (usually 4 hours at room temperature or 24 hours if refrigerated).

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Comprehensive Antibacterial Therapy

Imipenem Cilastatin Injection offers robust action against a wide range of bacterial pathogens. Ideal for serious or complicated infections, it is recommended when alternative antibiotics fail, ensuring effective and reliable clinical outcomes for adult patients under physician supervision.


Formulation and Packaging Details

This medication is provided as a dry powder injectable in a single vial per box, simplifying dosing for healthcare professionals. Each vial contains a combination of Imipenem 500mg and Cilastatin 500mg for dual-action efficacy.


Proper Usage and Administration

Imipenem Cilastatin Injection should only be administered by a healthcare professional via injection as prescribed by a physician. Dosage and frequency depend on the specific infection and patient factors, ensuring safety and optimal antibacterial effect.